Endocrine Abstracts

Pituitary carcinomas are rare and represent a challenge in clinical practice. Most secondary tumour localizations are intracranial and spinal, followed by liver, cervical lymph node, bone and, rarely, lung. PC frequently exhibit resistance to most usual therapies and the mean survival time is usually <4 years once metastases have been identified. Ectopic ACTH Syndrome is, in up to 50% cases, caused by lung tumours including carcinoids or Small Cell Lung Carcinomas (SCLC). ...

Introduction: Diabetes mellitus (DM) results from a defect in insulin secretion and/or its action. The Breast-Cancer Susceptibility Gene 2 (BRCA2), like BRCA1, is a tumour suppressor gene, and its mutation is associated with an increased risk of breast cancer and, in males, testicular cancer. In patients with the BRCA1/2 mutation, the level of Insulin-like Growth Factor (IGF)-1 and, consequently, the peripheral sensitivity to insulin are reduced, suggesting that this ...

We present a case of Inactivating PTH/PTHrP signalling disorder (IPPSD) revealed in aduthood in the context of respiratory alkalosis caused by covid-19 infection that led to worsening of the preexisting hypocalcemia and intensification of the usual hypocalcemic symptoms. A 39 year old female with history of subclinical hypothyroidism and bilateral cataracts was admited due to hypoxemia in the context of severe covid-19 infection with bilateral pulmonary infiltrates. She was vi...

Introduction: Insulinomas are the most frequent cause of hypoglycemia and the most common functional endocrine pancreatic tumors. Whipple triad is often present and should alert to the diagnosis.Case report: A 36-year-old male was admitted in the emergency room with loss of consciousness, diaphoresis and blurred vision, and hypoglycemia (50 mg/dl). The patient recalled recurrent symptoms of diaphoresis, tremors and palpitations, sometimes with loss of co...

Introduction: Thyroid storm is a rare medical emergency with high mortality, which usually results from acute exacerbation of hyperthyroidism. Amiodarone is a highly used class III antiarrhythmic drug and amiodarone-induced thyrotoxicosis is an infrequent effect of this medication, whose treatment may be difficult.Case study: A 20-year old male with congenital cardiomyopathy (Fallot tetralogy and Ebstein anomaly), chronically medicated with amiodarone 20...

Introduction: Radioiodine treatment (RAIT) is an effective definitive treatment for Graves’ Disease (GD) and Toxic Nodular Goiter (TNG). The aim of this study was to analyze demographic and clinical factors affecting the outcome of RAIT in patients with hyperthyroidism.Methods: Retrospective review of patients treated with RAIT for hyperthyroidism. A fixed dose of 10 mCi was administered to patients with GD and 15 mCi to patients with TNG. Treatment...

Introduction: Thyroglossal duct cysts (TDC) are a very frequent congenital neck mass and are mostly benign. Papillary thyroid carcinoma (PTC) originating from a TDC represents an infrequent finding. Usually, the diagnosis is only made postoperatively after cyst’s excision.Case report: A 38-years old female patient was referred to the Endocrinology department due to Graves’ disease. She had been treated with antithyroid drugs for 18 months witho...

Objectives: Assess the efficacy and safety of ultrasound-guided percutaneous ethanol injection (PEI) for treating benign cystic or predominantly cystic-thyroid nodules (TN).Methods: Retrospective analysis of all euthyroid patients treated with PEI for purely (>90% of cystic component) or predominantly cystic (50%-90% of cystic component) TN between January 2018 to February 2023. Efficacy was defined as 50% or greater reduction in pretreatment volume ...

Introduction: The deleterious effects of obesity on spontaneous reproduction are well recognized, although the literature on obesity and assisted reproductive technology outcome remains heterogeneous and inconsistent.Objective: To estimate the effect of BMI on ovarian stimulation response and live birth in women underwent in vitro fertilization (IVF).Methods: Retrospective observational study that included women submitted ...

Introduction: Adrenal insufficiency (AI) is a rare and potentially life-threatening disease. The most common causes are primary adrenal insufficiency (Addison’s Disease), due to an adrenocortical disease, and secondary insufficiency, due to disorders of the pituitary gland. Chronic glucocorticoid replacement is vital and patients should be educated about how to act in acute stress situations, in order to avoid adrenal crisis. Taking this into account, we organized educati...